About   Help   FAQ
Tg(Neurog3-cre/ERT2)1Able
Transgene Detail
Summary
Symbol: Tg(Neurog3-cre/ERT2)1Able
Name: transgene insertion 1, Andrew B Leiter
MGI ID: MGI:5449724
Synonyms: Ngn3-Cre/ERT2
Transgene: Tg(Neurog3-cre/ERT2)1Able  Location: unknown  
Alliance: Tg(Neurog3-cre/ERT2)1Able page
Transgene
origin
Strain of Origin:  C57BL/6 x (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Neurog3-cre/ERT2)1Able expression driven by 1 gene
 
Mutation details: Homologous recombination inserted the cre recombinase sequence fused to a mutated tamoxifen-inducible estrogen receptor (cre/ERT2) into the translation initiation ATG codon of the neurogenin 3 gene located in a BAC. Three founder lines were obtained which all produced nearly identical patterns of cre expression. A generic line 1 was created as representative. (J:190530)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Neurog3 (species not specified)
Summary of all recombinase alleles driven by Neurog3.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:190530 Li HJ, et al., Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol. 2012 Nov 15;371(2):156-69
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory