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Cdh6tm1.1(cre/ERT2)Jrs
Targeted Allele Detail
Summary
Symbol: Cdh6tm1.1(cre/ERT2)Jrs
Name: cadherin 6; targeted mutation 1.1, Joshua R Sanes
MGI ID: MGI:5461051
Synonyms: Cdh6-CreER, Cdh6tm1(cre/ERT)Jrs
Gene: Cdh6  Location: Chr15:13028787-13173761 bp, - strand  Genetic Position: Chr15, 6.11 cM
Alliance: Cdh6tm1.1(cre/ERT2)Jrs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190967
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Cdh6tm1.1(cre/ERT2)Jrs expression driven by 1 gene
 
Mutation details: The targeting vector contained (from 5' to 3') a cDNA sequence encoding the CreER fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain) with N-terminal 6xMyc tag, followed by an FRT-flanked SV40-neo selection cassette. This was inserted into the translational start site in the first coding exon of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. Mice were crossed to reporter animals for analysis. (J:190967)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdh6 (mouse)
Summary of all recombinase alleles driven by Cdh6.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh6 Mutation:  40 strains or lines available
References
Original:  J:190967 Kay JN, et al., Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections. J Neurosci. 2011 May 25;31(21):7753-62
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory