Bcl6<tm1.1Mtto> Targeted Allele Detail MGI Mouse (MGI:5461311)

Bcl6^tm1.1Mtto
Targeted Allele Detail

Summary

Symbol:	Bcl6^tm1.1Mtto
Name:	B cell leukemia/lymphoma 6; targeted mutation 1.1, Toshitada Takemori
MGI ID:	MGI:5461311
Synonyms:	Bcl6^f
Gene:	Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
Alliance:	Bcl6^tm1.1Mtto page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:190943
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette wiht a 5 loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the neo cassette and left exons 7 through 9 floxed. (J:190943)

Generation of the Bcl6^tm1.1Mtto allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

36 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:	57 strains or lines available

References

Original:	J:190943 Kaji T, et al., Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med. 2012 Oct 22;209(11):2079-97
All:	29 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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