Ptp4a3<tm1Geh> Targeted Allele Detail MGI Mouse (MGI:5461469)

Ptp4a3^tm1Geh
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Summary

Symbol:	Ptp4a3^tm1Geh
Name:	protein tyrosine phosphatase 4a3; targeted mutation 1, Gregg E Homanics
MGI ID:	MGI:5461469
Gene:	Ptp4a3 Location: Chr15:73594991-73629075 bp, + strand Genetic Position: Chr15, 34.05 cM, cytoband E1
Alliance:	Ptp4a3^tm1Geh page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:194458
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette. (J:194458)

Details of the generation of the Ptp4a3^tm1Geh and Ptp4a3^tm1.1Geh alleles

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ptp4a3 Mutation:	15 strains or lines available

References

Original:	J:194458 Zimmerman MW, et al., Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer. PLoS One. 2013;8(3):e58300
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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