Tbx18<tm2.1(cre)Sev> Targeted Allele Detail MGI Mouse (MGI:5461544)

Tbx18^{tm2.1(cre)Sev}
Targeted Allele Detail

Summary

Symbol:	Tbx18^{tm2.1(cre)Sev}
Name:	T-box18; targeted mutation 2.1, Sylvia Evans
MGI ID:	MGI:5461544
Synonyms:	Tbx18^Cre
Gene:	Tbx18 Location: Chr9:87584853-87613313 bp, - strand Genetic Position: Chr9, 47.06 cM, cytoband E3.2
Alliance:	Tbx18^{tm2.1(cre)Sev} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:191082
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Tbx18^{tm2.1(cre)Sev} expression driven by 1 gene

Mutation details: This is a modification of the Tbx18^tm2(cre)Sev allele. Briefly, a cre sequence and FRT-flanked neo cassette were inserted into the Tbx18 gene upstream of the initiation codon to generate the initial allele, and the neo was subsequently removed by crossing the original mice to a FLP deleter strain. (J:137459, J:191082)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx18 (mouse) Summary of all recombinase alleles driven by Tbx18. Alliance mouse Tbx18 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tbx18 Mutation:	36 strains or lines available

References

Original:	J:191082 Clavel C, et al., Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. Dev Cell. 2012 Nov 13;23(5):981-94
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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