Hdc<tm1.1(icre)Wwis> Targeted Allele Detail MGI Mouse (MGI:5461698)

Hdc^{tm1.1(icre)Wwis}
Targeted Allele Detail

Summary

Symbol:	Hdc^{tm1.1(icre)Wwis}
Name:	histidine decarboxylase; targeted mutation 1.1, William Wisden
MGI ID:	MGI:5461698
Synonyms:	HDC-Cre
Gene:	Hdc Location: Chr2:126435587-126461219 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband E5-G
Alliance:	Hdc^{tm1.1(icre)Wwis} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:188103
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Hdc^{tm1.1(icre)Wwis} expression driven by 1 gene

Mutation details: A targeting vector was generated to insert an improved IRES2i site, a humanized cre open reading frame and an FRT-flanked neo selection cassette into exon 12 of histidine decarboxylase between the stop codon and polyadenylation sequence, by homologous recombination in ES cells. Chimeras were produced by ES cell injection into C57BL/6J blastocysts. The resulting line was bred with Flp deleter mice to remove the neo cassette. (J:188103)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hdc (mouse) Summary of all recombinase alleles driven by Hdc. Comparative matrix view of recombinase activities Alliance mouse Hdc gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Hdc Mutation:	53 strains or lines available

References

Original:	J:188103 Zecharia AY, et al., GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci. 2012 Sep 19;32(38):13062-75
All:	11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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