Tg(Cyp11a1-icre)1Aswn
Transgene Detail
|
|
| Symbol: |
Tg(Cyp11a1-icre)1Aswn |
| Name: |
transgene insertion 1, Amanda Swain |
| MGI ID: |
MGI:5462056 |
| Synonyms: |
Cyp11a1-Cre |
| Transgene: |
Tg(Cyp11a1-icre)1Aswn Location: unknown
|
| Alliance: |
Tg(Cyp11a1-icre)1Aswn page
|
|
| Strain of Origin: |
Not Specified
|
|
| Transgene Type: |
|
Transgenic (Recombinase) |
| Mutation: |
|
Insertion
|
| |
|
Tg(Cyp11a1-icre)1Aswn expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Cyp11a1 |
|
|
| |
|
Mutation details: A targeting construct was generated with an improved cre coding region and rabbit beta-globin poly A signal sequence inserted into the 5' UTR of Cyp11a1, 14 bp upstream of the ATG codon. The construct contained a 2.8 kb Cyp11a1 fragment with the cre/poly A insertion (with a 100 bp deletion in Cyp11a1, including the ATG site). This fragment was introduced into bacterial cells for homologous recombination with a BAC containing the Cyp11a1 gene sequence. Recombined BAC DNA was purified for injection into fertilized pronuclei. One founder line was characterized by maing with two different mouse strains carrying cre-responsive reporters.
(J:189958)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Cyp11a1
(species not specified)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:189958 Buaas FW, et al., In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland. Development. 2012 Dec;139(24):4561-70 |
| All: |
2 reference(s) |
|
Analysis Tools
