Ccl2<tm1Lex> Targeted Allele Detail MGI Mouse (MGI:5462245)

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Ccl2^tm1Lex
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ccl2^tm1Lex
Name:	C-C motif chemokine ligand 2; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:5462245
Synonyms:	MCP-1^-
Gene:	Ccl2 Location: Chr11:81926403-81928278 bp, + strand Genetic Position: Chr11, 49.82 cM, cytoband C-E1
Alliance:	Ccl2^tm1Lex page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:191510
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A selection cassette replaced most of exon 2 (information provided by Taconic, see IMSR links).

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ccl2 Mutation:	25 strains or lines available

References

Original:	J:191510 Oh DY, et al., Increased macrophage migration into adipose tissue in obese mice. Diabetes. 2012 Feb;61(2):346-54
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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