Nubp1<m1Nisw> Chemically induced Allele Detail MGI Mouse (MGI:5463617)

Nubp1^m1Nisw
Chemically induced Allele Detail

Summary

Symbol:	Nubp1^m1Nisw
Name:	nucleotide binding protein 1; mutation 1, Lee Niswander
MGI ID:	MGI:5463617
Synonyms:	line3-2
Gene:	Nubp1 Location: Chr16:10229812-10242292 bp, + strand Genetic Position: Chr16, 5.61 cM
Alliance:	Nubp1^m1Nisw page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Nucleotide substitutions
		Mutation details: ENU induced two C to A transversions at position 743 and 803 resulting in a Threonine to Lysine and Proline to Glutamine amino acid change, respectively. Protein expression is detected in the distal lung epithelium; however the interaction with Nubp2 is disrupted in vitro. (J:191793)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Nubp1 Mutation:	17 strains or lines available

References

Original:	J:191793 Schnatwinkel C, et al., Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice. PLoS One. 2012;7(9):e44871
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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