Tg(Ikzf1-cre)GCayo
Transgene Detail
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| Symbol: |
Tg(Ikzf1-cre)GCayo |
| Name: |
transgene insertion G, Michel Cayouette |
| MGI ID: |
MGI:5465169 |
| Synonyms: |
IKCre-G |
| Transgene: |
Tg(Ikzf1-cre)GCayo Location: unknown
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| Alliance: |
Tg(Ikzf1-cre)GCayo page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Ikzf1-cre)GCayo expression driven by
1 gene
Transgene expression driven by:
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Mutation details: A BAC (RP23-373H2) containing the complete Ikzf1 gene (Ikaros) and large flanking sequences was modified by bacterial recombination to insert a cre-IRES-Venus cassette at the start codon in exon 2. An FRT-flanked neo selection cassette was also inserted. The neo was subsequently removed by Flp expression in bacteria for the final construct. The final construct was used for pronuclear injection to generated transgenic founders. 11 founder lines were obtained but only 9 produced transgenic progeny. Three founder lines (A,F, and G) were chosen for further analyses after crosses to reporter mice to assess recombination profiles. Line G labels isolated retinal progenitor cells.
(J:191133)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Ikzf1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:191133 Tarchini B, et al., In vivo evidence for unbiased Ikaros retinal lineages using an Ikaros-Cre mouse line driving clonal recombination. Dev Dyn. 2012 Dec;241(12):1973-85 |
| All: |
1 reference(s) |
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Analysis Tools
