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Rbm4btm1Wtarn
Targeted Allele Detail
Summary
Symbol: Rbm4btm1Wtarn
Name: RNA binding motif protein 4B; targeted mutation 1, Woan-Yuh Tarn
MGI ID: MGI:5467988
Gene: Rbm4b  Location: Chr19:4806480-4816199 bp, + strand  Genetic Position: Chr19, 4.11 cM
Alliance: Rbm4btm1Wtarn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192831
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A genomic fragment containing most of exon 2 was replaced with a promoterless DsRed-mammalian sterile 20 cassette and a floxed neo cassette via homologous recombination. RT-PCR confirmed the absence of mRNA expression in homozygous MEFs and detected an increase in expression of Rbm4 . (J:192831)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbm4b Mutation:  16 strains or lines available
References
Original:  J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory