Col1a1<tm1(tetO-CTNNB1)Tcd> Targeted Allele Detail MGI Mouse (MGI:5469323)

Col1a1^{tm1(tetO-CTNNB1)Tcd}
Targeted Allele Detail

Summary

Symbol:	Col1a1^{tm1(tetO-CTNNB1)Tcd}
Name:	collagen, type I, alpha 1; targeted mutation 1, TC Dale
MGI ID:	MGI:5469323
Synonyms:	Tet-OdeltaN89beta-catenin
Gene:	Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1^{tm1(tetO-CTNNB1)Tcd} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:193365
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Mutation
description

Allele Type:

Targeted (Inducible, Inserted expressed sequence)

Inducer:

doxycycline/tetracycline

Mutation:

Insertion

Col1a1^{tm1(tetO-CTNNB1)Tcd} expresses 1 gene

Col1a1^{tm1(tetO-CTNNB1)Tcd} expression driven by 1 gene

Mutation details: RCME on KH2 cells inserted a cassette that contains the tetracycline response element driving inducible expression of the truncated human cDNA (deltaN89) with MYC tag into the 3'UTR. (J:193365)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	163 strains or lines available

Notes

The allele was made in KH2 cells that carry Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} and Col1a1^{tm13(neo/hygro*)Jae}. This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

Original:	J:193365 Jarde T, et al., In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-ODeltaN89beta-catenin system. Oncogene. 2013 Feb 14;32(7):883-93
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24