Vps52t-w5+Art
Spontaneous Allele Detail
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| Symbol: |
Vps52t-w5+Art |
| Name: |
VPS52 GARP complex subunit; wild type revertant, Karen Artzt |
| MGI ID: |
MGI:5469354 |
| Gene: |
Vps52 Location: Chr17:34174786-34186009 bp, + strand Genetic Position: Chr17, 17.98 cM
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| Alliance: |
Vps52t-w5+Art page
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| Strain of Origin: |
wild-derived
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| Allele Type: |
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Spontaneous |
| Mutation: |
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Nucleotide repeat expansion
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Mutation details: A 3 nucleotide insertion of GGG is detected at the start of exon 2 in a stretch of consecutive G nucleotides (9 in the wild-type C57BL/6 sequence). The insertion of an additional G relative to Vps52t-w5 restores the reading frame to a wild-type reading frame. Western blot analysis with an antibody directed against amino acids 496-509 detects the protein band in kidney tissue from homozygous mice. This mutation is found in the tw5G haplotype.
(J:190873)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Vps52 Mutation: |
42 strains or lines available
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| Original: |
J:190873 Sugimoto M, et al., Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions. Cell Rep. 2012 Nov 29;2(5):1363-74 |
| All: |
1 reference(s) |
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Analysis Tools
