Otoa<tm1Gpr> Targeted Allele Detail MGI Mouse (MGI:5469411)

Otoa^tm1Gpr
Targeted Allele Detail

Summary

Symbol:	Otoa^tm1Gpr
Name:	otoancorin; targeted mutation 1, Guy P Richardson
MGI ID:	MGI:5469411
Synonyms:	Otoa^EGFP
Gene:	Otoa Location: Chr7:120682647-120762316 bp, + strand Genetic Position: Chr7, 65.07 cM
Alliance:	Otoa^tm1Gpr page

The tectorial membrane of Otoa^tm1Gpr/Otoa^tm1Gpr mice is detached from spiral limbus

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:192263
Parent Cell Line:	CCB (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: An EGFP and neo cassette was inserted downstream of exon 2. Immunohistochemistry confirmed the absence of protein expression in the cochlea. (J:192263)

Generation of the Otoa^tm1Gpr allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Otoa Mutation:	57 strains or lines available

References

Original:	J:192263 Lukashkin AN, et al., A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19351-6
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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