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Dll1tm1.1(cre/ERT2)Cle
Targeted Allele Detail
Summary
Symbol: Dll1tm1.1(cre/ERT2)Cle
Name: delta like canonical Notch ligand 1; targeted mutation 1.1, Hans Clevers
MGI ID: MGI:5473277
Synonyms: Dll1GFP-Creert2, Dll1GFP-ires-CreERT2
Gene: Dll1  Location: Chr17:15587616-15597134 bp, - strand  Genetic Position: Chr17, 8.95 cM
Alliance: Dll1tm1.1(cre/ERT2)Cle page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193937
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Dll1tm1.1(cre/ERT2)Cle expression driven by 1 gene
 
Mutation details: Homologous recombination was employed to insert an EGFP-IRES-cre/ERT2 cassette, Frt-flanked neo selection cassette and polyA signal into the ATG codon of exon 1 of Dll1 in ES cells. The neo marker was deleted in vivo by flippase (Flp) expression. GFP expression can be detected by confocal analysis in some mesenchymal cells and blood vessels, and in intestinal epithelial cells at the bottom and higher up in crypts. (J:193937)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dll1 (mouse)
Summary of all recombinase alleles driven by Dll1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dll1 Mutation:  46 strains or lines available
References
Original:  J:193937 van Es JH, et al., Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol. 2012 Oct;14(10):1099-104
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory