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Otx2tm1.1(cre/ERT2)Mgoe
Targeted Allele Detail
Summary
Symbol: Otx2tm1.1(cre/ERT2)Mgoe
Name: orthodenticle homeobox 2; targeted mutation 1.1, Magdalena Goetz
MGI ID: MGI:5473314
Synonyms: Otx2CreER
Gene: Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance: Otx2tm1.1(cre/ERT2)Mgoe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194049
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Otx2tm1.1(cre/ERT2)Mgoe expression driven by 1 gene
 
Mutation details: A cassette consisting of the cre/ERT2 sequence followed by the Otx2 3' UTR with the polyadenylation signal (and floxed neo marker) replaced the entire coding sequence of Otx2 following homologous recombination in ES cells. Founder animals were bred to CMV-deleter mice to remove the neo. (J:194049)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Otx2 (mouse)
Summary of all recombinase alleles driven by Otx2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  50 strains or lines available
References
Original:  J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory