Casp4del
Spontaneous Allele Detail
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| Symbol: |
Casp4del |
| Name: |
caspase 4, apoptosis-related cysteine peptidase; deletion |
| MGI ID: |
MGI:5473345 |
| Synonyms: |
Casp129 |
| Gene: |
Casp4 Location: Chr9:5308828-5336783 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1
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| Alliance: |
Casp4del page
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| Strain of Origin: |
129P3/J and 129S1/SvImJ and 129S2/SvPas and 129S6/SvEvTac and 129X1/SvJ
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| Allele Type: |
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Spontaneous (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: RT-PCR confirmed that five 129 substrains (129X1/SvJ, 129S1/SvImJ, 129S2/SvPas, 129S6/SvEvTac and 129P3/J) express a transcript that lacks exon 7 (delta110 isoform). Sequencing identified a 5 bp deletion in exon 7 that results in the fusion of exon 6 and 8, a frame-shift after proline 304 and a stop codon after 5 aberrant amino acids. This deletion is not present in C57BL/6. Western blot analysis confirmed the absence of protein expression in LPS-primed macrophage.
(J:193522)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:193522 Kayagaki N, et al., Non-canonical inflammasome activation targets caspase-11. Nature. 2011 Nov 3;479(7371):117-21 |
| All: |
68 reference(s) |
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Analysis Tools
