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Gad2tm1.1(cre/ERT2)Gmbk
Targeted Allele Detail
Summary
Symbol: Gad2tm1.1(cre/ERT2)Gmbk
Name: glutamic acid decarboxylase 2; targeted mutation 1.1, Gero Miesenboeck
MGI ID: MGI:5473402
Synonyms: Gad2::Cre-ERT2
Gene: Gad2  Location: Chr2:22512262-22583889 bp, + strand  Genetic Position: Chr2, 15.15 cM, cytoband A-B
Alliance: Gad2tm1.1(cre/ERT2)Gmbk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194305
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gad2tm1.1(cre/ERT2)Gmbk expression driven by 1 gene
 
Mutation details: A cassette encoding IRES-cre/ERT2 fused to an Frt-flanked neo resistance marker was inserted into the 3' untranslated region of the Gad2 gene immediately following the stop codon. The neo marker was excised excised by breeding founder animals ot Flp-expressing mice. (J:194305)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gad2 (mouse)
Summary of all recombinase alleles driven by Gad2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gad2 Mutation:  60 strains or lines available
References
Original:  J:194305 Katzel D, et al., The columnar and laminar organization of inhibitory connections to neocortical excitatory cells. Nat Neurosci. 2011 Jan;14(1):100-7
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory