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Flvcr1tm1Etol
Targeted Allele Detail
Summary
Symbol: Flvcr1tm1Etol
Name: feline leukemia virus subgroup C cellular receptor 1; targeted mutation 1, Emanuela Tolosano
MGI ID: MGI:5474636
Synonyms: Flvcr1a-
Gene: Flvcr1  Location: Chr1:190738044-190758355 bp, - strand  Genetic Position: Chr1, 96.28 cM
Alliance: Flvcr1tm1Etol page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194202
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Insertion
 
Mutation details: A neo cassette was inserted into the ATG start codon in the first exon. RT-PCR confirmed the absence of transcripts for isoform a in E13.5 embyos but an increase in isoform b transcripts. (J:194202)
Generation of the Flvcr1tm1Etol allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flvcr1 Mutation:  32 strains or lines available
References
Original:  J:194202 Chiabrando D, et al., The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest. 2012 Dec 3;122(12):4569-79
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory