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Dclk1tm1.1(cre/ERT2)Seno
Targeted Allele Detail
Summary
Symbol: Dclk1tm1.1(cre/ERT2)Seno
Name: doublecortin-like kinase 1; targeted mutation 1.1, Hiroshi Seno
MGI ID: MGI:5475100
Synonyms: Dclk1CreERT2
Gene: Dclk1  Location: Chr3:55149785-55446489 bp, + strand  Genetic Position: Chr3, 26.53 cM, cytoband D
Alliance: Dclk1tm1.1(cre/ERT2)Seno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193873
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Dclk1tm1.1(cre/ERT2)Seno expression driven by 1 gene
 
Mutation details: Homologous recombination was employed to insert a cre/ERT2-IRES-EGFP-polyA-Frt-neo-Frt cassette into the Dclk1 gene immediately after the ATG start codon in exon 2. After germline transmission was established, the neo cassette was excised in vivo by crossing mutants to Flp-expressing mice. (J:193873)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dclk1 (mouse)
Summary of all recombinase alleles driven by Dclk1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dclk1 Mutation:  55 strains or lines available
References
Original:  J:193873 Nakanishi Y, et al., Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet. 2013 Jan;45(1):98-103
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory