About   Help   FAQ
Pdgfratm1.1(cre/Esr1*)Nshk
Targeted Allele Detail
Summary
Symbol: Pdgfratm1.1(cre/Esr1*)Nshk
Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 1, Shin-Ichi Nishikawa
MGI ID: MGI:5475226
Synonyms: PRalpha-MCM
Gene: Pdgfra  Location: Chr5:75312953-75358876 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Pdgfratm1.1(cre/Esr1*)Nshk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193389
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Pdgfratm1.1(cre/Esr1*)Nshk expression driven by 1 gene
 
Mutation details: A targeting vector was constructed with Pdgfra homology arms, the tamoxifen-inducible MerCreMer cDNA with an adenoviral splice acceptor sequence (SA) added to the 5' side of the MCM cDNA to prevent cryptic splicing and an Frt-flanked neo cassette 3' to the the MCM sequence. This construct was injected into ES cells. Flp excised the neo cassette from the final allele. (J:193389)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdgfra (mouse)
Summary of all recombinase alleles driven by Pdgfra.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfra Mutation:  88 strains or lines available
References
Original:  J:193389 Ding G, et al., PDGF Receptor Alpha+ Mesoderm Contributes to Endothelial and Hematopoietic Cells in Mice. Dev Dyn. 2013 Mar;242(3):254-68
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory