Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh
Transgene Detail
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| Symbol: |
Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh |
| Name: |
transgene insertion 2, Gunter J Hammerling |
| MGI ID: |
MGI:5476442 |
| Synonyms: |
CD11c.LuciDTR |
| Transgene: |
Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh Location: unknown
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| Alliance: |
Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence, Recombinase) |
| Mutation: |
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Insertion
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Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
HBEGF (1839) |
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Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Itgax (MGI:96609) |
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Mutation details: A cDNA construct encoding EGFP, cre recombinase, human diphtheria toxin receptor (DTR; HBEGF) and click beetle green 99 (CBG99) luciferase was generated, with coding sequences separated by self-cleaving 2A viral sequences. The presence of 2A sequences results in stoichiometric translation of the individual proteins. This construct was inserted at the ATG start codon of Itgax in the RPCI-24-7812 bacterial artificial chromosome by recombineering in bacterial cells. The modified BAC was linearized and injected into pronuclei of fertilized C57BL/6N oocytes and line 2 was established.
(J:194800)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Itgax
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:194800 Tittel AP, et al., Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods. 2012 Apr;9(4):385-90 |
| All: |
2 reference(s) |
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Analysis Tools
