Gt(ROSA)26Sortm4.1(RARE-YFP)Mgn
Targeted Allele Detail
|
Symbol: |
Gt(ROSA)26Sortm4.1(RARE-YFP)Mgn |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 4.1, Mark A Magnussen |
MGI ID: |
MGI:5476524 |
Synonyms: |
-228/DR5-TA-YFP |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
|
Alliance: |
Gt(ROSA)26Sortm4.1(RARE-YFP)Mgn page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:195112
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129S6/SvEvTac
|
|
Allele Type: |
|
Targeted |
Mutation: |
|
Insertion
|
|
|
Mutation details: This allele was created by RMCE in Gt(ROSA)26Sortm1Mgn. The original selections cassettes (puromycin N-acetyltransferase and a truncated form of HSV1 thymidine kinase and EM7-driven neomycin resistance) were replaced by a cassette composed of ROSA26 upstream sequence deleted from the start codon to -228, 5X direct repeat of a DR5 (AGGTCAccaggAGGTCA) which is a consensus RARE controlling expression of the YFP reporter. An upstream FLP flanked hygromycin selection cassette was subsequently removed by flp recombinase.
(J:195112)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Gt(ROSA)26Sor Mutation: |
986 strains or lines available
|
|
|
Original: |
J:195112 Serup P, et al., Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Dis Model Mech. 2012 Nov;5(6):956-66 |
All: |
1 reference(s) |
|