Gt(ROSA)26Sortm8.1(Ctnnb1-CFP)Mgn
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm8.1(Ctnnb1-CFP)Mgn |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 8.1, Mark A Magnussen |
MGI ID: |
MGI:5476536 |
Synonyms: |
-60 SuTOP-TA-CFP |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm8.1(Ctnnb1-CFP)Mgn page
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Germline Transmission: |
Earliest citation of germline transmission:
J:195112
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (RMCE-ready, Reporter) |
Mutation: |
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Insertion
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Mutation details: This allele was created by RMCE in Gt(ROSA)26Sortm1Mgn. The original selections cassettes (puromycin N-acetyltransferase and a truncated form of HSV1 thymidine kinase and EM7-driven neomycin resistance) were replaced by a cassette composed of ROSA26 upstream sequence deleted from the start codon to -60, mutant TCF/LEF binding sites from the Ctnnb1 gene controlling expression of the CFP reporter. An upstream FLP flanked hygromycin selection cassette was subsequently removed by flp recombinase.
(J:195112)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
997 strains or lines available
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Original: |
J:195112 Serup P, et al., Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Dis Model Mech. 2012 Nov;5(6):956-66 |
All: |
2 reference(s) |
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