Stx11<tm1.2Ics> Targeted Allele Detail MGI Mouse (MGI:5476622)

Stx11^tm1.2Ics
Targeted Allele Detail

Summary

Symbol:	Stx11^tm1.2Ics
Name:	syntaxin 11; targeted mutation 1.2, Mouse Clinical Institute
MGI ID:	MGI:5476622
Gene:	Stx11 Location: Chr10:12813953-12840042 bp, - strand Genetic Position: Chr10, 4.54 cM, cytoband A2
Alliance:	Stx11^tm1.2Ics page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:193137
Parent Cell Line:	BD10 (ES Cell)
Strain of Origin:	C57BL/6NTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A resistance cassette (FRT site, neo resistance gene, loxP site, FRT site and loxP site) was inserted downstream of exon 3. An additional loxP site was inserted upstream of exon 3. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in CD8+ T cells. (J:193137)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Stx11 Mutation:	10 strains or lines available

References

Original:	J:193137 Sepulveda FE, et al., Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood. 2013 Jan 24;121(4):595-603
All:	3 reference(s)

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