Sftpc<tm1.1(cre/ERT2)Ptch> Targeted Allele Detail MGI Mouse (MGI:5485991)

Sftpc^{tm1.1(cre/ERT2)Ptch}
Targeted Allele Detail

Summary

Symbol:	Sftpc^{tm1.1(cre/ERT2)Ptch}
Name:	surfactant associated protein C; targeted mutation 1.1, Pao-Tien Chuang
MGI ID:	MGI:5485991
Synonyms:	SPC^CreER
Gene:	Sftpc Location: Chr14:70758389-70761521 bp, - strand Genetic Position: Chr14, 36.32 cM
Alliance:	Sftpc^{tm1.1(cre/ERT2)Ptch} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:195738
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Sftpc^{tm1.1(cre/ERT2)Ptch} expression driven by 1 gene

Mutation details: The translational start ATG of the Sftpc gene was replaced with a cre/ERT Frt-PGK-neo-Frt cassette (containing 3 copies of the polyadenylation signal) by homologous recombination in ES cells. The neo marker was removed by crosses to Tg(ACTFLPe)9205 mice. (J:195738)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sftpc (mouse) Summary of all recombinase alleles driven by Sftpc. Alliance mouse Sftpc gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Sftpc Mutation:	24 strains or lines available

References

Original:	J:195738 Lin C, et al., Alveolar type II cells possess the capability of initiating lung tumor development. PLoS One. 2012;7(12):e53817
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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