Pgrtm1.1(cre)Shah
Targeted Allele Detail
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| Symbol: |
Pgrtm1.1(cre)Shah |
| Name: |
progesterone receptor; targeted mutation 1.1, Nirao M Shah |
| MGI ID: |
MGI:5487679 |
| Synonyms: |
PRCre |
| Gene: |
Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
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| Alliance: |
Pgrtm1.1(cre)Shah page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:196278
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129S/SvEv
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Pgrtm1.1(cre)Shah expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Pgr (MGI:97567) |
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Mutation details: A construct was designed to insert an internal ribosome entry site (IRES), cre recombinase gene, Frt site, RNA pol II-Neo-HSVtk-polyA cassette, and a second Frt site downstream of the progesterone receptor (Pgr) transcriptonal stop codon. The construct was electroporated into 129S/SvEv-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts.
Chimeric males were bred with C57BL/6J females to establish the colony. At some point, mutant mice were bred with GtROSA-FLPe mice (undisclosed genetic background) to remove the frt-flanked neo cassette.
(J:196278)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Pgr
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:196278 Yang CF, et al., Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell. 2013 May 9;153(4):896-909 |
| All: |
20 reference(s) |
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Analysis Tools
