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Egr3tm1.1(cre)Wgt
Targeted Allele Detail
Summary
Symbol: Egr3tm1.1(cre)Wgt
Name: early growth response 3; targeted mutation 1.1, Warren G Tourtellotte
MGI ID: MGI:5489890
Synonyms: Egr3Cre
Gene: Egr3  Location: Chr14:70314766-70320062 bp, + strand  Genetic Position: Chr14, 36.2 cM, cytoband D1
Alliance: Egr3tm1.1(cre)Wgt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196371
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Egr3tm1.1(cre)Wgt expression driven by 1 gene
 
Mutation details: By homologous recombination, a targeting construct replaced the endogenous exon 1, intron, and exon 2 of Egr3 with a cassette encoding nuclear-localized cre recombinase with and a PGK-neo selection marker flanked with forward-oriented Frt sites. The neo was excised from the germline by mating mice to CAG-FLPe mice. (J:196371)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Egr3 (mouse)
Summary of all recombinase alleles driven by Egr3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egr3 Mutation:  17 strains or lines available
References
Original:  J:196371 Quach DH, et al., A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci. 2013 Mar 6;33(10):4570-83
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory