Stra6tm1Nbg
Targeted Allele Detail
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| Symbol: |
Stra6tm1Nbg |
| Name: |
stimulated by retinoic acid gene 6; targeted mutation 1, Norbert B Ghyselinck |
| MGI ID: |
MGI:5490784 |
| Synonyms: |
Stra6L-, Stra6tm2.2Nbg |
| Gene: |
Stra6 Location: Chr9:57971071-58061279 bp, + strand Genetic Position: Chr9, 31.63 cM, cytoband C
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| Alliance: |
Stra6tm1Nbg page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:196841
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exons 5 through 7. Western blot analysis confirmed the absence of protein expression in E9.5 embryos and the retinal pigment epithelium. This allele was generated from Stra6tm2.1.
(J:196841, J:203449)
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Generation of the Stra6tm2.1Nbg and Stra6tm1Nbg alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Stra6 Mutation: |
50 strains or lines available
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| Original: |
J:196841 Ruiz A, et al., Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Vis Sci. 2012;53(6):3027-39 |
| All: |
4 reference(s) |
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Analysis Tools
