Tg(Sox2-cre/Esr1*)20Jheb
Transgene Detail
|
|
| Symbol: |
Tg(Sox2-cre/Esr1*)20Jheb |
| Name: |
transgene insertion 20, Jean M Hebert |
| MGI ID: |
MGI:5494289 |
| Synonyms: |
Sox2-CreER, Sox2-CreERTM |
| Transgene: |
Tg(Sox2-cre/Esr1*)20Jheb Location: unknown
|
| Alliance: |
Tg(Sox2-cre/Esr1*)20Jheb page
|
|
|
|
| Transgene Type: |
|
Transgenic (Inducible, Recombinase) |
| Inducer: |
|
tamoxifen |
| Mutation: |
|
Insertion
|
| |
|
Tg(Sox2-cre/Esr1*)20Jheb expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Sox2 (MGI:98364) |
|
|
| |
|
Mutation details: The coding sequence of the Sox2 gene in a BAC (RP23-2B8) was replaced with the coding sequence for a tamoxifen-inducible cre/estrogen receptor fusion (cre/Esr1*; CreERTM). The construct was injected into pronuclei of fertilized FVB oocytes. 3 transgene-positive founders were obtained (20, 34, and 36). Founders were bred to reporter mice, administered tamoxifen at E9.5, and embryos were analyzed for recombination activity at E10.5. Line 20 progeny displayed the strongest lacZ expression. This line was characterized further.
(J:195589)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Sox2
(mouse)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:195589 Kang W, et al., A Sox2 BAC transgenic approach for targeting adult neural stem cells. PLoS One. 2012;7(11):e49038 |
| All: |
1 reference(s) |
|
Analysis Tools
