Tg(H2-Aa-HLA-DPA1)1Lone
Transgene Detail
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| Symbol: |
Tg(H2-Aa-HLA-DPA1)1Lone |
| Name: |
transgene insertion 1, Yu Chun Lone |
| MGI ID: |
MGI:5494673 |
| Synonyms: |
Tg(HLA-DPA103) |
| Transgene: |
Tg(H2-Aa-HLA-DPA1)1Lone Location: unknown
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| Alliance: |
Tg(H2-Aa-HLA-DPA1)1Lone page
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| Strain of Origin: |
C57BL/6 x DBA/2
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: This transgene contains a full length cDNA encoding the 01:03 variant of the alpha chain of the human major histocompatibility complex (MHC) class II DP receptor (HLA-DPA1*1:03) inserted into a mouse genomic DNA fragment downstream of the promoter of the histocompatibility 2, class II antigen A, alpha (H2-Aa) locus. The human cDNA is followed by the mouse H2-Aa 3' noncoding sequence. Mice bearing this transgene in combination with Tg(H2-Ab1-HLA-DPB1)1Lone express a human HLA-DPalpha103/DPbeta401 complex that is specifically recognized by the anti-HLA-DP monoclonal antibody B72.
(J:197820)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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| Original: |
J:197820 Lemonnier F, et al., Transgenic mice and use thereof as an experimental model. Patent Application US20100138936 A1. 2010; |
| All: |
11 reference(s) |
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