Tg(Tshb-cre)4Sac
Transgene Detail
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| Symbol: |
Tg(Tshb-cre)4Sac |
| Name: |
transgene insertion 4, Sally A Camper |
| MGI ID: |
MGI:5495135 |
| Synonyms: |
Tg(Tshb-cre), Tg(Tshb-cre)4Sac |
| Transgene: |
Tg(Tshb-cre)4Sac Location: unknown
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| Alliance: |
Tg(Tshb-cre)4Sac page
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| Strain of Origin: |
(C57BL/6 x SJL)F2
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Tshb-cre)4Sac expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Tshb |
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Mutation details: Recombineering methods generated a construct in which a cre recombinase cassette was inserted at the transcriptional start site of Tshb in a BAC. Microinjection of the construct generated 4 cre-expressing founders which were crossed to reporter mice for activity analyses. Three lines demonstrated moderate levels of activity in the pituitary gland, but the activity was not specific to thyrotrophs. The other founder line 4 showed higher activity with greater thyrotroph specificity and was selected for further analysis.
(J:197591)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Tshb
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:197591 Castinetti F, et al., PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism. Mol Endocrinol. 2011 Nov;25(11):1950-60 |
| All: |
3 reference(s) |
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Analysis Tools
