Dbh<tm1(flpo)Pjen> Targeted Allele Detail MGI Mouse (MGI:5495939)

Dbh^{tm1(flpo)Pjen}
Targeted Allele Detail

Summary

Symbol:	Dbh^{tm1(flpo)Pjen}
Name:	dopamine beta hydroxylase; targeted mutation 1, Patricia Jensen
MGI ID:	MGI:5495939
Synonyms:	Dbh^Flpo
Gene:	Dbh Location: Chr2:27055519-27073216 bp, + strand Genetic Position: Chr2, 19.29 cM
Alliance:	Dbh^{tm1(flpo)Pjen} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:198264
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutations:

Insertion, Intragenic deletion

Dbh^{tm1(flpo)Pjen} expression driven by 1 gene

Mutation details: A Flpo cassette and a loxP-flanked PGK/Em7-Neo cassette was inserted by homologous recombination at the start codon of the Dbh gene, replacing 107 bp of exon 1. (J:198264)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dbh (mouse) Summary of all recombinase alleles driven by Dbh. Alliance mouse Dbh gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Dbh Mutation:	17 strains or lines available

References

Original:	J:198264 Robertson SD, et al., Developmental origins of central norepinephrine neuron diversity. Nat Neurosci. 2013 Aug;16(8):1016-23
All:	4 reference(s)

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