Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Myh6-cre)TG9Pjay
Name:	transgene insertion TG9, Patrick Y Jay
MGI ID:	MGI:5496902
Synonyms:	DCM-TG9, TG 9
Transgene:	Tg(Myh6-cre)TG9Pjay  Location: unknown
Alliance:	Tg(Myh6-cre)TG9Pjay page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Myh6-cre)TG9Pjay expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Myh6   Mutation details: cDNA encoding cre recombinase was cloned into a vector containing a 5.8 kb fragment of the Myh6 (alpha-MHC) promoter including the promoter region and exons 1-3 with the hGH polyadenylation site 3' to the Myh6 fragment. The purified construct was microinjected into male pronuclei of fertilized FVB/N oocytes. 6 founders died with signs of congestive heart failure before germline transmission was established. Two founders transmitted the transgene to produce lines TG 9 and TG 12. TG9 mice developed severe cardiomyopathy and died of heart failure at 11-13 weeks. TG12 animals did not show any pathological cardiac phenotype. The TG9 line was investigated in detail. TG9 cre protein levels are much higher than in TG12 animals, and 50-100 fold higher than in Tg(Myhca-cre)1Abel mice. (J:198043)

Activity:	Tissue activity of this recombinase allele
Driver:	Myh6 (species not specified) Summary of all recombinase alleles driven by Myh6.

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:198043 Buerger A, et al., Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 2006 Jun;12(5):392-8
All:	6 reference(s)