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Nos3tm2.1Plh
Targeted Allele Detail
Summary
Symbol: Nos3tm2.1Plh
Name: nitric oxide synthase 3, endothelial cell; targeted mutation 2.1, Paul L Huang
MGI ID: MGI:5499171
Synonyms: eNosS1176A, eNosSA
Gene: Nos3  Location: Chr5:24569808-24589472 bp, + strand  Genetic Position: Chr5, 11.32 cM
Alliance: Nos3tm2.1Plh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198075
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details: Exon 26 was replaced with a modified one in which nucleotide substitions result in the amino acid substitution of alanine for serine at position 1176 (S1176A). Cre-mediated recombination removed a floxed neomycin resistance cassette. The predicted protein contains an unphosphorylatable (SA) mutation. (J:198075)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nos3 Mutation:  58 strains or lines available
References
Original:  J:198075 Kashiwagi S, et al., eNOS phosphorylation on serine 1176 affects insulin sensitivity and adiposity. Biochem Biophys Res Commun. 2013 Feb 8;431(2):284-90
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory