Col1a1<tm1(tetO-CDKN2A)Ibp> Targeted Allele Detail MGI Mouse (MGI:5502558)

Col1a1^{tm1(tetO-CDKN2A)Ibp}
Targeted Allele Detail

Summary

Symbol:	Col1a1^{tm1(tetO-CDKN2A)Ibp}
Name:	collagen, type I, alpha 1; targeted mutation 1, Ittai Ben-Porath
MGI ID:	MGI:5502558
Synonyms:	tet-p14
Gene:	Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1^{tm1(tetO-CDKN2A)Ibp} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:196969
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Mutation
description

Allele Type:

Targeted (Inducible, Inserted expressed sequence, RMCE-ready)

Inducer:

doxycycline/tetracycline

Mutation:

Insertion

Col1a1^{tm1(tetO-CDKN2A)Ibp} expresses 1 gene

Col1a1^{tm1(tetO-CDKN2A)Ibp} expression driven by 1 gene

Mutation details: RMCE on KH2 ES cells introduced into the 3' UTR a tetracycline responsive element driving inducible expression of the human cDNA. (J:196969)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	163 strains or lines available

Notes

The allele was made in KH2 cells that carry Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} and Col1a1^{tm13(neo/hygro*)Jae}. This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

Original:	J:196969 Tokarsky-Amiel R, et al., Dynamics of Senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis. Cancer Res. 2013 May 1;73(9):2829-39
All:	2 reference(s)

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