Ptf1a/Ptf1aostm1Kymm
Targeted Allele Detail
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| Symbol: |
Ptf1a/Ptf1aostm1Kymm |
| Name: |
pancreas specific transcription factor, 1a; targeted mutation 1, Ken-ichi Yamamura |
| MGI ID: |
MGI:5502928 |
| Synonyms: |
Gm13336-Ptf1aneo |
| Gene: |
Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
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| Alliance: |
Ptf1a/Ptf1aostm1Kymm page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:195133
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: A loxP site, FRT site, neomycin resistance cassette, lox2272 site, polyadenylation sequence and FRT site replaced exon 1 of Ptf1a and exons 1 and 2 of Ptf1aos. RT-PCR confirmed the abscence of transcript expression of both transcripts in E9.5 embryos. This allele was generated in ES cells containing Etn2Sd.
(J:195133)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: C57BL/6 | |
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| Phenotypes: |
| Affected Systems |
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endocrine/exocrine glands
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√
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absent pancreas
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√
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limbs/digits/tail
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√
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abnormal tail morphology
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√
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skeleton
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√
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abnormal skeleton morphology
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ptf1a Mutation: |
29 strains or lines available
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| Original: |
J:195133 Semba K, et al., Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet. 2013 Feb;9(2):e1003204 |
| All: |
1 reference(s) |
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Analysis Tools
