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Shox2tm3.1(cre)Ypc
Targeted Allele Detail
Summary
Symbol: Shox2tm3.1(cre)Ypc
Name: SHOX homeobox 2; targeted mutation 3.1, YiPing Chen
MGI ID: MGI:5504508
Synonyms: Shox2Cre
Gene: Shox2  Location: Chr3:66879060-66889104 bp, - strand  Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
Alliance: Shox2tm3.1(cre)Ypc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199319
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Shox2tm3.1(cre)Ypc expression driven by 1 gene
 
Mutation details: A targeting vector introduced the cre recombinase coding sequence and an frt-flanked PGK-neo selection cassette into the Shox2 locus via homologous recombination in ES cells, replacing exon 1, intron 1 and part of exon 2. Germline animals were crossed to Flp deleter mice to remove the PGK-neo cassette. (J:199319)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Shox2 (mouse)
Summary of all recombinase alleles driven by Shox2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shox2 Mutation:  20 strains or lines available
References
Original:  J:199319 Sun C, et al., Generation of Shox2-Cre allele for tissue specific manipulation of genes in the developing heart, palate, and limb. Genesis. 2013 Jul;51(7):515-22
All:  11 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory