Tg(Retn-cre)1Laz
Transgene Detail
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| Symbol: |
Tg(Retn-cre)1Laz |
| Name: |
transgene insertion 1, Mitchell A Lazar |
| MGI ID: |
MGI:5505690 |
| Synonyms: |
Retn-Cre |
| Transgene: |
Tg(Retn-cre)1Laz Location: unknown
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| Alliance: |
Tg(Retn-cre)1Laz page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Retn-cre)1Laz expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Retn |
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Mutation details: A BAC containing the resistin (Retn) gene was modified by inserting a fragmemt encoding a nuclear localization signal (NLS) sequence, cre recombinase, and a polyadenylation signal in front of the start codon of Retn. Start sites of other genes in the BAC were mutated to prevent aberrant transcription. The purified construct was injected into fertilized C57BL/6 oocytes and founders were produced. These were crossed to wild-type and the mice were mated to ROSA26R reporter mice to assess cre activity. The line exhibiting the greatest specificity and efficiency was used for subsequent analysis.
(J:199860)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Retn
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:199860 Mullican SE, et al., A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods. Mol Endocrinol. 2013 Jan;27(1):127-34 |
| All: |
2 reference(s) |
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Analysis Tools
