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Runx3tm1.1(cre/ERT2)Tmj
Targeted Allele Detail
Summary
Symbol: Runx3tm1.1(cre/ERT2)Tmj
Name: runt related transcription factor 3; targeted mutation 1.1, Thomas M Jessell
MGI ID: MGI:5505843
Synonyms: Rx3:CreER
Gene: Runx3  Location: Chr4:134847963-134905301 bp, + strand  Genetic Position: Chr4, 67.19 cM
Alliance: Runx3tm1.1(cre/ERT2)Tmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197913
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Runx3tm1.1(cre/ERT2)Tmj expression driven by 1 gene
 
Mutation details: An IRES-cre/ERT2-Frt-PGKneo-Frt cassette was inserted into the Runx3 gene just downstream of the stop codon in exon 6. Germline mutants were crossed to Flp expressing mice to remove the neo marker. (J:197913)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Runx3 (mouse)
Summary of all recombinase alleles driven by Runx3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx3 Mutation:  27 strains or lines available
References
Original:  J:197913 de Nooij JC, et al., Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets. Neuron. 2013 Mar 20;77(6):1055-68
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory