Tg(CAG-XBP1*/cre/ERT2)#Grtn
Transgene Detail
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| Symbol: |
Tg(CAG-XBP1*/cre/ERT2)#Grtn |
| Name: |
transgene insertion, Florian R Greten |
| MGI ID: |
MGI:5507828 |
| Synonyms: |
Xbp1s-creERT2 |
| Transgene: |
Tg(CAG-XBP1*/cre/ERT2)#Grtn Location: unknown
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| Alliance: |
Tg(CAG-XBP1*/cre/ERT2)#Grtn page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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cellular stress and tamoxifen |
| Mutation: |
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Insertion
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Tg(CAG-XBP1*/cre/ERT2)#Grtn expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| chicken |
CAG |
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Mutation details: The pCAX-F-XBP1/deltaDBD-venus plasmid construct was modified by replacing the venus cDNA with cDNA encoding a cre/ERT2 fusion protein. The final construct consists of nucleotides 410-633 of a human XBP1 cDNA including a Kozak sequence and FLAG-tag coding sequence fused to cre/ERT2 cDNA under control of a CAG promoter construct. The XBP1 fragment lacks the DNA binding domain but includes a 26-nt endoplasmic reticulum stress-specific intron. Under normal conditions, the mRNA of the fusion gene is not spliced and translation terminates at a stop codon near the junction of XBP1 and cre/ERT2. During ER stress, the 26 nt intron is spliced out and the XBP1/cre/ERT2 mRNA is transcribed. Founder and line number information is not available.
(J:197481)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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CAG
(chicken)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:197481 Schwitalla S, et al., Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 2013 Jan 17;152(1-2):25-38 |
| All: |
2 reference(s) |
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Analysis Tools
