Tg(T-cre/ERT2)1Lwd Transgene Detail MGI Mouse (MGI:5509185)

Tg(T-cre/ERT2)1Lwd
Transgene Detail

Summary

Symbol:	Tg(T-cre/ERT2)1Lwd
Name:	transgene insertion 1, Mark Lewandoski
MGI ID:	MGI:5509185
Synonyms:	TCreERT2
Transgene:	Tg(T-cre/ERT2)1Lwd Location: unknown
Alliance:	Tg(T-cre/ERT2)1Lwd page

Transgene
origin

Strain of Origin:

(C57BL/6NCr x C3H/HeNCr)F2

Transgene
description

Transgene Type:

Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Tg(T-cre/ERT2)1Lwd expression driven by 1 gene

Mutation details: The cre recombinase coding region fused to the sequence for a mutated ligand-binding domain of the human estrogen receptor was inserted into a construct where it is under the control of the 500 bp brachyury (T) promoter. Eight transgenic lines were generated and one showed extensive cre activity in presence of tamoxifen but little without tamoxifen induction. (J:200549)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	T (species not specified) Summary of all recombinase alleles driven by T.

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Zygotes for injection were derived by intercrossing B6C3F1 (C57BL/6NCr X C3H/HeNCrMTV) mice.

References

Original:	J:200549 Anderson MJ, et al., TCreERT2, a transgenic mouse line for temporal control of Cre-mediated recombination in lineages emerging from the primitive streak or tail bud. PLoS One. 2013;8(4):e62479
All:	7 reference(s)

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