Psaptm4.1Ggb
Targeted Allele Detail
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| Symbol: |
Psaptm4.1Ggb |
| Name: |
prosaposin; targeted mutation 4.1, Gregory A Grabowski |
| MGI ID: |
MGI:5510529 |
| Synonyms: |
AB- |
| Gene: |
Psap Location: Chr10:60113449-60138376 bp, + strand Genetic Position: Chr10, 30.02 cM
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| Alliance: |
Psaptm4.1Ggb page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:198242
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129S/SvEv
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| Allele Type: |
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Targeted |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Nucleotide substitutions result in the amino acid substitution of Cys 4 of saposins A and B located in exon 4 (saposin A domain) and exon 7 (saposin B domain) with phenylalanine. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modified exon 7. Western blot analysis confirmed the absence of saponin A and B, overexpression of saponin C and normal expression of saponin D in the cerebrum and liver.
(J:198242)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Psap Mutation: |
36 strains or lines available
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| Original: |
J:198242 Sun Y, et al., Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Hum Mol Genet. 2013 Jun 15;22(12):2435-50 |
| All: |
1 reference(s) |
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Analysis Tools
