Fktn<tm3.1Ttd> Targeted Allele Detail MGI Mouse (MGI:5514346)

Fktn^tm3.1Ttd
Targeted Allele Detail

Summary

Symbol:	Fktn^tm3.1Ttd
Name:	fukutin; targeted mutation 3.1, Tatsushi Toda
MGI ID:	MGI:5514346
Synonyms:	fukutin^lox
Gene:	Fktn Location: Chr4:53713745-53765785 bp, + strand Genetic Position: Chr4, 28.74 cM
Alliance:	Fktn^tm3.1Ttd page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:198535
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:198535)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fktn Mutation:	44 strains or lines available

References

Original:	J:198535 Kanagawa M, et al., Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression. Hum Mol Genet. 2013 Aug 1;22(15):3003-15
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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