Muc19<tm2Culp> Targeted Allele Detail MGI Mouse (MGI:5515435)

Muc19^tm2Culp
Targeted Allele Detail

Summary

Symbol:	Muc19^tm2Culp
Name:	mucin 19; targeted mutation 2, David Culp
MGI ID:	MGI:5515435
Gene:	Muc19 Location: Chr15:91722531-91832440 bp, + strand Genetic Position: Chr15, 46.14 cM, cytoband E3
Alliance:	Muc19^tm2Culp page

Sublingual gland abnormalities in Muc19^tm2Culp/Muc19^tm2Culp, and Muc19^sld/Muc19^sld adults

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:199625
Parent Cell Line:	CMTI-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 20 through 25 were replaced with a floxed neomycin resistance/STOP cassette. Western blot analysis confirmed the absence of protein expression in the sublingual gland. (J:199625)

Generation of the Muc19^tm2Culp allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Muc19 Mutation:	41 strains or lines available

References

Original:	J:199625 Das B, et al., The sld genetic defect: two intronic CA repeats promote insertion of the subsequent intron and mRNA decay. J Biol Chem. 2013 May 24;288(21):14742-55
All:	1 reference(s)

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