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Trp53tm1.1Thst
Targeted Allele Detail
Summary
Symbol: Trp53tm1.1Thst
Name: transformation related protein 53; targeted mutation 1.1, Thorsten Stiewe
MGI ID: MGI:5518934
Synonyms: p53RR, Trp53E177R, Trp53R177E
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm1.1Thst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198482
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details: Exon 5 was replaced with a modified one in which nucleotide substitutions (GA-to-AG) result in the amino acid substitution of glutamic acid with arginine at position 177 (p.E177R), mimicking a mutation found in some human tumors. Cre-mediated recombination removed the loxP site flanked puromycin resistance gene cassette inserted into intron 1. (J:198482)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 76 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Trp53tm1.1Thst
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  240 strains or lines available
References
Original:  J:198482 Timofeev O, et al., p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell Rep. 2013 May 30;3(5):1512-25
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory