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Tg(Hoxa5-cre)447BLjea
Transgene Detail
Summary
Symbol: Tg(Hoxa5-cre)447BLjea
Name: transgene insertion 447B, Lucie Jeannotte
MGI ID: MGI:5518947
Synonyms: Tg(14.5kb Hoxa5-cre)Ljea
Transgene: Tg(Hoxa5-cre)447BLjea  Location: unknown  
Alliance: Tg(Hoxa5-cre)447BLjea page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Hoxa5-cre)447BLjea expression driven by 1 gene
 
Mutation details: A 5 kb genomic fragment of Hoxa5 (containing the temporal (T) control region, the brachial spinal cord (BSC) enhancer, proximal Hoxa5 promoter, both exons and the intron of Hoxa5) drives cre epxression in this transgene. An IRES-EGFPcre cassette was inserted into exon 1 of Hoxa5 downstream of the translation initiation codon. A 2.1 kb fragment containing the mesodermal (MES) enhancer and an additional 7.4-kb of downstream sequences including an enhancer driving lung and gut (L/G) expression were added at the 3' end of the construct to produce the 14.5 Hoxa5/Cre transgene. Eight founder lines were obtained and line 447B was established. This line has 6 copies of the transgene. (J:207917)
Generation of Tg(Hoxa5-cre)447BLjea.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hoxa5 (species not specified)
Summary of all recombinase alleles driven by Hoxa5.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:207917 Berube-Simard FA, et al., Hoxa5/Cre transgenic mice: novel tools for regional deletion along the anterior-posterior axis. Genesis. 2014 Feb;52(2):149-56
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory