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Tnctm1(cre/ERT2)Cmha
Targeted Allele Detail
Summary
Symbol: Tnctm1(cre/ERT2)Cmha
Name: tenascin C; targeted mutation 1, Chuan-Ming Hao
MGI ID: MGI:5520052
Synonyms: Tenascin-C-CreER2, TncYFP-CreER
Gene: Tnc  Location: Chr4:63878022-63965252 bp, - strand  Genetic Position: Chr4, 34.06 cM
Alliance: Tnctm1(cre/ERT2)Cmha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202522
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tnctm1(cre/ERT2)Cmha expression driven by 1 gene
 
Mutation details: Using homologous recombination, a cre/ERT2-IRES-EGFP cassette was inserted immediately upstream of the translation start ATG codon in exon 2 of the tenascin C gene. A neo selection marker flanked by frt sites followed the cre cassette. EGFP expression is similar to endogenous Tnc expression in the kidney inner medulla interstitial cells. No significant cre-dependent reporter activity is observed in absence of tamoxifen treatment. (J:202522)
Generation of Tnctm1(cre/ERT2)Cmha.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tnc (mouse)
Summary of all recombinase alleles driven by Tnc.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnc Mutation:  135 strains or lines available
References
Original:  J:202522 He W, et al., Generation of a Tenascin-C-CreER2 Knockin Mouse Line for Conditional DNA Recombination in Renal Medullary Interstitial Cells. PLoS One. 2013;8(11):e79839
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory