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Avptm1.1(cre)Hze
Targeted Allele Detail
Summary
Symbol: Avptm1.1(cre)Hze
Name: arginine vasopressin; targeted mutation 1.1, Hongkui Zeng
MGI ID: MGI:5522761
Synonyms: AVP-IRES2-Cre, AVP-IRES2-Cre-D, AVP-IRES2-Cre-DeltaNeo, AVPm1(IRES2-Cre)Hze
Gene: Avp  Location: Chr2:130422540-130424474 bp, - strand  Genetic Position: Chr2, 63.24 cM
Alliance: Avptm1.1(cre)Hze page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220523
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Avptm1.1(cre)Hze expression driven by 1 gene
 
Mutation details: The targeting vector contained, from 5' to 3', a partial Avp sequence spanning exon 1 through intron 1, an frt3 site within Avp intron 1, a partial Avp intron 1 sequence up to and including the endogenous stop codon in exon 3, an internal ribosome entry site 2 (IRES2) sequence (allows translation initiation in the middle of an mRNA sequence), a Cre recombinase gene,a bovine growth hormone polyA sequence, an AttB site, a PGK promoter-Neomycin resistance gene-PGK polyA cassette, an frt5 site, an mRNA splice acceptor, the 3' portion of the hygromycin gene (Hygro2) with SV40 late polyA signal, and an AttP site. This construct was electroporated into (129S6/SvEvTac x C57BL/6)F1-derived G4 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric mice were bred to PhiC31-expressing mice to remove the AttB/AttP-flanked PGK-neo sequence and replace it with the recombined AttB/AttP site (AttL). (J:202880, J:220523)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Avp (mouse)
Summary of all recombinase alleles driven by Avp.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Avp Mutation:  19 strains or lines available
References
Original:  J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76
All:  31 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory