Exo1tm3.1Wed
Targeted Allele Detail
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| Symbol: |
Exo1tm3.1Wed |
| Name: |
exonuclease 1; targeted mutation 3.1, Winfried Edelmann |
| MGI ID: |
MGI:5523450 |
| Synonyms: |
Exo1EK |
| Gene: |
Exo1 Location: Chr1:175708334-175738962 bp, + strand Genetic Position: Chr1, 81.9 cM
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| Alliance: |
Exo1tm3.1Wed page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:198719
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Humanized sequence) |
| Mutations: |
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Insertion, Single point mutation
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Mutation details: Glutamic acid codon 109 (GAG) was changed to lysine (AAG) (p.E109K). This mutation corresponds to one found in patients with hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Cre-mediated recombination removed the loxP site flanked neomycin resistance cassette that was inserted into intron 5. Western blot analysis confirmed the presence of protein expression in the testis. The product of this allele lacks exonuclease activity.
(J:198719)
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Gene targeting strategy for the Exo1tm3.1Wed allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Exo1 Mutation: |
46 strains or lines available
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| Original: |
J:198719 Schaetzlein S, et al., Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2470-9 |
| All: |
1 reference(s) |
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Analysis Tools
